p-Toluenesulfonic acid monohydrate → HCID 89962145, compound

HRID 337961Notes

Reaction equation

HRID 337961 reaction equation
[F:1][C:2]1([F:14])[CH2:7][CH2:6][C:5]([C:9]2[CH:10]=[N:11][NH:12][CH:13]=2)(O)[CH2:4][CH2:3]1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[F:14][C:2]1([F:1])[CH2:7][CH2:6][C:5]([C:9]2[CH:13]=[N:12][NH:11][CH:10]=2)=[CH:4][CH2:3]1

Participants

4

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 89962750HCID 89962750, compound

Product 1

HCID 89962145HCID 89962145, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 99b by using the 4,4-difluoro-1-(1H-pyrazol-4-yl)cyclohexanol (0.25 g, 1.24 mmol) prepared in Example 143a, p-toluenesulfonic acid monohydrate (120 mg, 0.62 mmol) and toluene (3.0 mL), to yield the title compound (189 mg, 83%) as a colorless solid.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-db941650f31d49e882bdd7968242f005
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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