HCID 89962245, compound → HCID 89962729, compound

HRID 338019Notes

Reaction equation

HRID 338019 reaction equation
[Si:1]([O:8][C@@H:9]1[CH2:14][CH2:13][C@H:12]([OH:15])[C@@H:11]([C:16]2[N:20]([CH3:21])[N:19]=[CH:18][CH:17]=2)[CH2:10]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]>CCCCCC.C(O)(C)C>[Si:1]([O:8][C@H:9]1[CH2:14][CH2:13][C@@H:12]([OH:15])[C@H:11]([C:16]2[N:20]([CH3:21])[N:19]=[CH:18][CH:17]=2)[CH2:10]1)([C:4]([CH3:7])([CH3:5])[CH3:6])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 89962245HCID 89962245, compound

Product 1

HCID 89962729HCID 89962729, compound

Reagents, catalysts & solvents 1

HCID 21585144Isopropanol hexaneSolvent

Procedure

The (1S*,2R*,4R*)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(1-methyl-1H-pyrazol-5-yl)cyclohexanol prepared in Example 161a was optically resolved with CHIRALFLASH IC (Daicel Corp.; hexane/isopropanol=6:4) to yield the title compound as a colorless oil.

Sources & evidence

ORD record
ord-16cd94aa1b8c4e64a113263ae7e1581e
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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