Hydrochloric Acid → HCID 86762253, compound

HRID 338171Notes

Reaction equation

HRID 338171 reaction equation
[F:1][C:2]1[S:6][C:5]([C@:7]23[CH2:15][N:14]([C:16]4[N:21]=[CH:20][CH:19]=[CH:18][N:17]=4)[CH2:13][C@H:12]2[CH2:11][S:10][C:9]([NH2:22])=[N:8]3)=[CH:4][CH:3]=1.[ClH:23]>C(OCC)C.ClCCl>[ClH:23].[F:1][C:2]1[S:6][C:5]([C@:7]23[CH2:15][N:14]([C:16]4[N:17]=[CH:18][CH:19]=[CH:20][N:21]=4)[CH2:13][C@H:12]2[CH2:11][S:10][C:9]([NH2:22])=[N:8]3)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86762246HCID 86762246, compound

Product 1

HCID 86762253HCID 86762253, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolvent2×HCID 6344DichloromethaneSolvent

Procedure

To a stirred clear colorless solution of the [(4aR,7aR)-7a-(5-fluorothiophen-2-yl)-6-(pyrimidin-2-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-amine (318 mg, 948 μmol) in diethyl ether (10 mL) and dichloromethane (10 mL) is added a solution of 1 M HCl in diethyl ether (1.05 mL, 1.05 mmol). The resulting white mixture is stirred for a few minutes, then the solid is collected and washed with diethyl ether (15 mL), to give the title compound (325 mg, 92%) as a white solid. ES/MS (m/e): 336.0 (M+H).

Workup

  1. customthe solid is collected
  2. washwashed with diethyl ether (15 mL)

Sources & evidence

ORD record
ord-ff049e61700949c1a23ae8c3c1e55d28
Source dataset
uspto-grants-2014_11
Patent number
US08889856B2

Reaction notes

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