Hydrochloric Acid → HCID 86762254, compound

Participants

Reaction Steps

To a stirred clear colorless solution of [(4aR,7aR)-6-(5-fluoropyrimidin-2-yl)-7a-(5-fluorothiophen-2-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-amine (255 mg, 722 μmol) and diethyl ether (10 mL) is added a solution of 1 M HCl in diethyl ether (794 μL, 794 μmol). The resulting white mixture is stirred for a few minutes and the resulting solid collected and rinsed with diethyl ether (10 mL), to give the title compound (274 mg, 97%) as a white solid. ES/MS (m/e): 354.0 (M+H).

Provenance & Evidence