Hydrochloric Acid → HCID 86762254, compound

HRID 338172Notes

Reaction equation

HRID 338172 reaction equation
[F:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:16][C@@H:15]3[C@@:10]([C:18]4[S:19][C:20]([F:23])=[CH:21][CH:22]=4)([N:11]=[C:12]([NH2:17])[S:13][CH2:14]3)[CH2:9]2)=[N:6][CH:7]=1.[ClH:24]>C(OCC)C>[ClH:24].[F:1][C:2]1[CH:7]=[N:6][C:5]([N:8]2[CH2:16][C@@H:15]3[C@@:10]([C:18]4[S:19][C:20]([F:23])=[CH:21][CH:22]=4)([N:11]=[C:12]([NH2:17])[S:13][CH2:14]3)[CH2:9]2)=[N:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86762248HCID 86762248, compound

Product 1

HCID 86762254HCID 86762254, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a stirred clear colorless solution of [(4aR,7aR)-6-(5-fluoropyrimidin-2-yl)-7a-(5-fluorothiophen-2-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-amine (255 mg, 722 μmol) and diethyl ether (10 mL) is added a solution of 1 M HCl in diethyl ether (794 μL, 794 μmol). The resulting white mixture is stirred for a few minutes and the resulting solid collected and rinsed with diethyl ether (10 mL), to give the title compound (274 mg, 97%) as a white solid. ES/MS (m/e): 354.0 (M+H).

Workup

  1. customthe resulting solid collected
  2. washrinsed with diethyl ether (10 mL)

Sources & evidence

ORD record
ord-4ecb166e6a804915b54afa7e0c66699c
Source dataset
uspto-grants-2014_11
Patent number
US08889856B2

Reaction notes

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