反应详情

To a stirred solution of the 5-[(4aR,7aR)-2-amino-6-[5-fluoro-4-(2-hydroxypropan-2-yl)pyrimidin-2-yl]-4a,5,6,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a(4H)-yl]thiophene-2-carbonitrile (256 mg, 612 μmol) in diethyl ether (20 mL) is added a solution of 1 M HCl in diethyl ether (673 μL, 0.673 mmol). The resulting white mixture is stirred for a few minutes, and then the solid is collected by vacuum filtration, and is rinsed with diethyl ether, to give the title compound (201 mg, 72%) as a white solid. MS/ES (m/z) 419.2 (M+H).

1. filtrationthe solid is collected by vacuum filtration
2. washis rinsed with diethyl ether