Acetone → Di-Tert-Butyl Iodomethyl Phosphate

HRID 338176Notes

Reaction equation

HRID 338176 reaction equation
[P:1]([O:13][CH2:14]Cl)([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[I-:16].[Na+].CC(C)=O>C(#N)C>[P:1]([O:13][CH2:14][I:16])([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

5

Reactant 3

HCID 180AcetoneHCID 5238Sodium IodideHCID 11701630Di-tert-butyl (chloromethyl) phosphate2×

Product 1

HCID 58196853Di-Tert-Butyl Iodomethyl Phosphate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound was prepared by halogen exchange reaction of di-tert-butyl chloromethyl phosphate (Intermediate 1) with sodium iodide in suitable solvent such as dry acetone or acetonitrile.

Sources & evidence

ORD record
ord-8d4e9d0acf66499eadee976bb46cb036
Source dataset
uspto-grants-2014_11
Patent number
US08889862B2

Reaction notes

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