Hydrogen chloride-ethyl acetate → 1-(3-(4-Bromophenoxy)propyl)piperazine

HRID 338345Notes

Reaction equation

HRID 338345 reaction equation
[Br:1][C:2]1[CH:24]=[CH:23][C:5]([O:6][CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.Cl.C(OCC)(=O)C>C(OCC)(=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH2:8][CH2:9][N:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86698690Tert-butyl 4-(3-(4-bromophenoxy)propyl)piperazine-1-carboxylate

Product 1

HCID 185402171-(3-(4-Bromophenoxy)propyl)piperazineYield 100.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of tert-butyl 4-(3-(4-bromophenoxy)propyl)piperazine-1-carboxylate (200 mg, 0.50 mmol) in ethyl acetate (10 mL) was added HCl/ethyl acetate (20 mL). The mixture was stirred at rt for 4 hours. The mixture was concentrated to give the title compound (150 mg, 100% yield) as a white solid.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-80808231162c49e7923a5ccf649ae953
Source dataset
uspto-grants-2014_11
Patent number
US08889730B2

Reaction notes

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