反应详情

The mixture of 4-bromo-2-fluorobenzaldehyde (6.1 g, 0.03 mol) and sodium methoxide (1.78 g, 0.033 mol) in dry methanol (60 mL) was stirred at reflux for 16 hours. The methanol was evaporated. The residue was partitioned between DCM and water. The organic layers were dried over sodium sulfate, concentrated in vacuo to give a yellow solid, which was purified by silica gel chromatography (Petroleum ether/EtOAc=20:1 to 10:1) to give the title compound (6.3 g, 97%) as a light yellow solid.

1. temperatureat reflux for 16 hours
2. customThe methanol was evaporated
3. customThe residue was partitioned between DCM and water
4. dry with materialThe organic layers were dried over sodium sulfate
5. concentrationconcentrated in vacuo
6. customto give a yellow solid, which
7. customwas purified by silica gel chromatography (Petroleum ether/EtOAc=20:1 to 10:1)