Trifluoroacetic acid → HCID 86698867, compound

HRID 338552Notes

Reaction equation

HRID 338552 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH:9]([CH3:31])[CH2:10][O:11]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[I:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH:9]([CH3:31])[CH2:10][OH:11])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86698866HCID 86698866, compound

Product 1

HCID 86698867HCID 86698867, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-iodo-4-{[1-(trityloxy)propan-2-yl]oxy}benzene (350 mg, 0.67 mmol) in dichloromethane (5 mL) was added trifluoroacetic acid (5 mL). The mixture was stirred at room temperature for 4 hours. The reaction mixture was concentrated and purified by combiflash (petroleum ether:ethyl acetate=10:1 to 4:1) to give the title compound (100 mg, 55%) as a white solid, which was used into next step directly.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by combiflash (petroleum ether:ethyl acetate=10:1 to 4:1)

Sources & evidence

ORD record
ord-1dd1ac58593440b5998886fc77471819
Source dataset
uspto-grants-2014_11
Patent number
US08889730B2

Reaction notes

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