Methylamine → 1-(benzo[d][1,3]dioxol-5-yl)-N-(5-((2-methoxyphenyl)(methylamino)methyl)pyridin-2-yl)cyclopropanecarboxamide

HRID 338598Notes

Reaction equation

HRID 338598 reaction equation
CS(OC(C1C=NC(NC(C2(C3C=CC4OCOC=4C=3)CC2)=O)=CC=1)C1C=CC=CC=1OC)(=O)=O.CN.[O:38]1[C:42]2[CH:43]=[CH:44][C:45]([C:47]3([C:50]([NH:52][C:53]4[CH:58]=[CH:57][C:56]([CH:59]([N:68](C)[CH3:69])[C:60]5[CH:65]=[CH:64][CH:63]=[CH:62][C:61]=5[O:66][CH3:67])=[CH:55][N:54]=4)=[O:51])[CH2:49][CH2:48]3)=[CH:46][C:41]=2[O:40][CH2:39]1>>[O:38]1[C:42]2[CH:43]=[CH:44][C:45]([C:47]3([C:50]([NH:52][C:53]4[CH:58]=[CH:57][C:56]([CH:59]([C:60]5[CH:65]=[CH:64][CH:63]=[CH:62][C:61]=5[O:66][CH3:67])[NH:68][CH3:69])=[CH:55][N:54]=4)=[O:51])[CH2:49][CH2:48]3)=[CH:46][C:41]=2[O:40][CH2:39]1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 442364971-(benzo[d][1,3]dioxol-5-yl)-N-(5-((dimethylamino)(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamideHCID 57895126(6-(1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)pyridin-3-yl)(2-methoxyphenyl)methyl methanesulfonate

Product 1

HCID 578951201-(benzo[d][1,3]dioxol-5-yl)-N-(5-((2-methoxyphenyl)(methylamino)methyl)pyridin-2-yl)cyclopropanecarboxamide

Procedure

1-(benzo[d][1,3]dioxol-5-yl)-N-(5-((2-methoxyphenyl)(methylamino)methyl)pyridin-2-yl)cyclopropanecarboxamide was prepared from (6-(1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)pyridin-3-yl)(2-methoxyphenyl)methyl methanesulfonate and methyl amine in a manner analogous to that of 1-(benzo[d][1,3]dioxol-5-yl)-N-(5-((dimethylamino)(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamide.

Sources & evidence

ORD record
ord-8110b7890f4d4d899bdad3511ef1bc80
Source dataset
uspto-grants-2014_11
Patent number
US08889875B2

Reaction notes

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