3-Isopropylaniline → N-(3-isopropylphenyl)-6-(2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)picolinamide
Reaction equation
[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:12][N:11]([C:13]3[N:18]=[C:17]([C:19]([OH:21])=O)[CH:16]=[CH:15][CH:14]=3)[CH2:10][CH2:9][C:7]=2[N:8]=1.[CH:22]([C:25]1[CH:26]=[C:27]([CH:29]=[CH:30][CH:31]=1)[NH2:28])([CH3:24])[CH3:23]>>[CH:22]([C:25]1[CH:26]=[C:27]([NH:28][C:19](=[O:21])[C:17]2[CH:16]=[CH:15][CH:14]=[C:13]([N:11]3[CH2:10][CH2:9][C:7]4[N:8]=[C:3]([S:2][CH3:1])[N:4]=[CH:5][C:6]=4[CH2:12]3)[N:18]=2)[CH:29]=[CH:30][CH:31]=1)([CH3:24])[CH3:23]Participants
3
Procedure
In a manner similar to that described in Example 108, a mixture of 6-[2-(methylthio)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-6-yl]pyridine-2-carboxylic acid and 3-isopropylaniline were converted to the title compound (560 mg).
Sources & evidence
- ORD record
- ord-25716feea5964748b21a1269e318b7a2
- Source dataset
- uspto-grants-2014_11
- Patent number
- US08889870B2
Reaction notes
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