4-Isopropylaniline → 2-Bromo-N-(4-isopropyl-phenyl)-isonicotinamide

HRID 338718Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([OH:7])=O.[CH:11]([C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1)([CH3:13])[CH3:12]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([NH:18][C:17]1[CH:19]=[CH:20][C:14]([CH:11]([CH3:13])[CH3:12])=[CH:15][CH:16]=1)=[O:7]

Participants

Reactant 2

HCID 74644-Isopropylaniline

HCID 2227012-Bromoisonicotinic acid

Product 1

HCID 866958442-Bromo-N-(4-isopropyl-phenyl)-isonicotinamide

Procedure

In a manner similar to that described in Preparation 17, 2-bromoisonicotinic acid and 4-isopropylaniline were converted to the title compound

Sources & evidence

ORD record: ord-527d4cc478294f31b192d1c4257e2cb7
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08889870B2

Reaction notes

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