2-(Methylthio)-5,6,7,8-tetrahydropyrido[4,3-D]pyrimidine → 2-[2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]-N-phenylisonicotinamide

HRID 338719Notes

Reaction equation

HRID 338719 reaction equation
[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:12][NH:11][CH2:10][CH2:9][C:7]=2[N:8]=1.Br[C:14]1[CH:15]=[C:16]([CH:26]=[CH:27][N:28]=1)[C:17]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:18]>>[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:12][N:11]([C:14]3[CH:15]=[C:16]([CH:26]=[CH:27][N:28]=3)[C:17]([NH:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:18])[CH2:10][CH2:9][C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 552636702-(Methylthio)-5,6,7,8-tetrahydropyrido[4,3-D]pyrimidineHCID 866958402-Bromo-N-phenyl-isonicotinamide

Product 1

HCID 866958452-[2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]-N-phenylisonicotinamide

Procedure

In a manner similar to that described for Example 138, 2-(methylsulfanyl)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine and 2-bromo-N-phenyl-isonicotinamide were converted to the title compound.

Sources & evidence

ORD record
ord-3522751c16ba4f2bba13953332442d9f
Source dataset
uspto-grants-2014_11
Patent number
US08889870B2

Reaction notes

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