反应详情

To a solution of tert-butyl 2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate (1.43 g, 5.36 mmol) in dichloromethane (10 mL) was added a solution of trifluoroacetic acid (4.0 mL, 52 mmol) in dichloromethane (5 mL). The solution was stirred at room temperature for 3 hours. The dichloromethane was removed in vacuo. The residue was dissolved in water, treated with 5M sodium hydroxide to pH=14 and extracted with dichloromethane (5×10 mL). The organic layer was dried (MgSO4) filtered and evaporated to give the title compound (870 mg, 97%).

1. customThe dichloromethane was removed in vacuo
2. dissolutionThe residue was dissolved in water
3. additiontreated with 5M sodium hydroxide to pH=14
4. extractionextracted with dichloromethane (5×10 mL)
5. dry with materialThe organic layer was dried (MgSO4)
6. filtrationfiltered
7. customevaporated