4-Isopropylaniline → 4-bromo-N-(4-isopropylphenyl)picolinamide

HRID 338729Notes

Reaction equation

HRID 338729 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([OH:10])=O)[CH:3]=1.[CH:11]([C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1)([CH3:13])[CH3:12]>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([NH:18][C:17]2[CH:19]=[CH:20][C:14]([CH:11]([CH3:13])[CH3:12])=[CH:15][CH:16]=2)=[O:10])[CH:3]=1

Participants

3

Reactant 2

HCID 74644-IsopropylanilineHCID 7351504-Bromopyridine-2-carboxylic acid

Product 1

HCID 866958534-bromo-N-(4-isopropylphenyl)picolinamide

Procedure

In a manner similar to that describe in Preparation 34, 4-bromo-pyridine-2-carboxylic acid and 4-isopropylaniline were converted to the title compound.

Sources & evidence

ORD record
ord-c021e8db769a4e4095512e7ac1413513
Source dataset
uspto-grants-2014_11
Patent number
US08889870B2

Reaction notes

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