反应详情

温度

60 °C

To a solution of 3-Dimethylamino-1-pyridin-4-yl-propenone (590 mg) in methanol (10 ml) was added acetic acid (0.5 ml) and (4-Benzyloxy-phenyl)-hydrazine hydrogen chloride (836 mg) and the reaction mixture heated to 60° C. for 6 h. The reaction mixture was poured into saturated sodium bicarbonate, extracted with ethyl acetate, dried magnesium sulfate, filtered and concentrated. Purification via combiflash MPLC provided the title compound (795 mg). MS: (M+H m/z=328.1).

1. extractionextracted with ethyl acetate, dried magnesium sulfate
2. filtrationfiltered
3. concentrationconcentrated
4. customPurification via combiflash MPLC