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In an ethanol solvent, 1 N ethoxy sodium (NaOEt) (1.1 eq.) was added dropwise to 3-hydroxybenzaldehyde (1.0 eq.) and ethyl α-bromoisobutyrate (1.1 eq.), and the reaction mixture was refluxed. After the ethanol was evaporated, the residual was distributed between ethyl acetate and water, and an organic layer was dried by using MgSO4, filtered, and evaporated. The residual was purified by silica gel column chromatography using hexane and ethyl acetate (8:1) to obtain Compound 97b.

1. temperaturethe reaction mixture was refluxed
2. customAfter the ethanol was evaporated
3. customan organic layer was dried
4. filtrationfiltered
5. customevaporated
6. customThe residual was purified by silica gel column chromatography