2-Aminothiophenol → 2-(4-(Benzo[d]thiazol-2-yl)phenoxy)-2-methylpropanoic acid

HRID 338798Notes

Reaction equation

HRID 338798 reaction equation
C([CH2:3][C:4]([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]=O)=[CH:12][CH:11]=1)([CH3:8])[C:5]([OH:7])=[O:6])C.[NH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[SH:25]>CO>[S:25]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[C:16]1[C:13]1[CH:12]=[CH:11][C:10]([O:9][C:4]([CH3:3])([CH3:8])[C:5]([OH:7])=[O:6])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 87132-AminothiophenolHCID 86709921Ethyl 2-(4-formylphenoxy)-2-methylpropanoic acid

Product 1

HCID 601946872-(4-(Benzo[d]thiazol-2-yl)phenoxy)-2-methylpropanoic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a methanol solvent, a solution including Compound 97c (1.0 eq.) and 2-aminothiophenol (1.0 eq.) was stirred at room temperature. After methanol was removed, the precipitate was filtered, and washed with cold methanol to obtain a solid target product.

Workup

  1. customAfter methanol was removed
  2. filtrationthe precipitate was filtered
  3. washwashed with cold methanol
  4. customto obtain a solid target product

Sources & evidence

ORD record
ord-c8091baed8be4d3a89607f90b517ec91
Source dataset
uspto-grants-2014_11
Patent number
US08889881B2

Reaction notes

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