反应详情

温度

100 °C

In a DMF (3 mL) solvent, a solution including 2-amino-4-trifluoromethylbenzenethiol (100 mg, 0.44 mmol) and 3-bromo-4-hydroxybenzaldehyde (88.4 mg, 0.44 mmol) was heated at a temperature of 100° C. for 2.5 hours. After DMF was evaporated, the residual was distributed between methylene chloride and water, and an organic layer was evaporated. The produced solid was filtered, and washed with ethyl acetate to obain a solid Compound 119.

1. customAfter DMF was evaporated
2. customan organic layer was evaporated
3. filtrationThe produced solid was filtered
4. washwashed with ethyl acetate