反应详情

A solution of methyl 6-hydrazinylnicotinate (1.00 g, 5.98 mmol) and 8-tert-butylquinoline-2-carbaldehyde (1.28 g, 5.98 mmol) in absolute ethanol (20 mL) was stirred at ambient temperature for 4 hours. The solid that formed was collected by filtration, washed with ethanol (10 mL), ether (100 mL) and dried to give (E)-methyl 6-(2-((8-tert-butylquinolin-2-yl)methylene)hydrazinyl)nicotinate (1.78 g, 82.1%) as a solid.

1. customThe solid that formed
2. filtrationwas collected by filtration
3. washwashed with ethanol (10 mL), ether (100 mL)
4. customdried