Methyl 6-hydrazinylpyridine-3-carboxylate → methyl 6-[(2E)-2-[(8-tert-butylquinolin-2-yl)methylidene]hydrazinyl]pyridine-3-carboxylate

Participants

Reaction Steps

A solution of methyl 6-hydrazinylnicotinate (1.00 g, 5.98 mmol) and 8-tert-butylquinoline-2-carbaldehyde (1.28 g, 5.98 mmol) in absolute ethanol (20 mL) was stirred at ambient temperature for 4 hours. The solid that formed was collected by filtration, washed with ethanol (10 mL), ether (100 mL) and dried to give (E)-methyl 6-(2-((8-tert-butylquinolin-2-yl)methylene)hydrazinyl)nicotinate (1.78 g, 82.1%) as a solid.

Provenance & Evidence