HCID 70917093, compound → HCID 86707430, compound

HRID 338882Notes

Reaction equation

HRID 338882 reaction equation
[CH:1]1([C:4]2[C:12]([N+:13]([O-])=O)=[CH:11][CH:10]=[CH:9][C:5]=2[C:6]([OH:8])=[O:7])[CH2:3][CH2:2]1.[H][H]>CO.[Pt]>[NH2:13][C:12]1[C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([OH:8])=[O:7]

Participants

5

Reactant 2

HCID 70917093HCID 70917093, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86707430HCID 86707430, compoundYield 94.7%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

A solution of 2-cyclopropyl-3-nitrobenzoic acid (0.63 g, 3.04 mmol) and 5% Pt/C (0.59 g, 0.152 mmol) in methanol (10 mL) was charged with 40 psi of hydrogen and shaken for 3 hours. The catalyst was removed by filtration and washed with methanol (10 mL). The filtrate was concentrated under reduced pressure to give 3-amino-2-cyclopropylbenzoic acid (0.51 g, 94.1%) as a solid.

Workup

  1. customThe catalyst was removed by filtration
  2. washwashed with methanol (10 mL)
  3. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-6787cd14dd654a098df909d4bdf3b89c
Source dataset
uspto-grants-2014_11
Patent number
US08889704B2

Reaction notes

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