Acetic Acid → HCID 70984126, compound

HRID 338902Notes

Reaction equation

HRID 338902 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([CH:12](C(OCC)=O)[C:13]([O:15]CC)=[O:14])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.Cl.C(O)(=O)C>O>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([CH2:12][C:13]([OH:15])=[O:14])[CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 70983315Diethyl 2-(2-methylquinolin-8-yl)malonate

Product 1

HCID 70984126HCID 70984126, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of diethyl 2-(2-methylquinolin-8-yl)malonate (2.34 g, 7.77 mmol), 6 N HCl (7.77 mL, 46.6 mmol) in water, and acetic acid (7.77 mL) was heated at 106° C. for 18 hours. After cooling to ambient temperature, the solvent was removed under reduced pressure to give 2-(2-methylquinolin-8-yl)acetic acid (1.56 g, 99.8%) as a solid.

Workup

  1. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-ae21fd09de2e4248bd81f912a9f729f0
Source dataset
uspto-grants-2014_11
Patent number
US08889704B2

Reaction notes

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