反应详情

To 4-fluoro-2-methoxyaniline (370 mg, 2.62 mmol) in refluxing 6N HCl (5 mL) was added dropwise (E)-but-2-enal (367 mg, 5.24 mmol). The reaction was heated to reflux for 2 hours then cooled and neutralized with NH4OH. The aqueous phase was extracted with DCM, and the combined organic phases dried over MgSO4 and concentrated to yield 6-fluoro-8-methoxy-2-methylquinoline (500 mg, 99.8% yield) as a brown solid.

1. temperatureThe reaction was heated
2. temperatureto reflux for 2 hours
3. temperaturethen cooled
4. extractionThe aqueous phase was extracted with DCM
5. dry with materialthe combined organic phases dried over MgSO4
6. concentrationconcentrated