反应详情

To 6-fluoro-7-isopropoxy-2-methylquinoline (270 mg, 1.23 mmol) in dioxane/water (5 mL/0.05 mL) was added selenium dioxide (164 mg, 1.48 mmol) and the reaction was heated to reflux for 2 hours. After cooling and concentrating, the residue was purified by chromatography (SP4, 25M, eluting with a gradient of water/ACN 100:0 to 0:100, 20 column volumes) to yield 6-fluoro-7-isopropoxyquinoline-2-carbaldehyde as a solid.

1. temperaturethe reaction was heated
2. temperatureto reflux for 2 hours
3. temperatureAfter cooling
4. concentrationconcentrating
5. customthe residue was purified by chromatography (SP4, 25M
6. washeluting with a gradient of water/ACN 100:0 to 0:100, 20 column volumes)