HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 7-Ethoxy-6-fluoroquinoline-2-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Selenium Dioxide | HCID 24007 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | 7-Ethoxy-6-fluoro-2-methylquinoline | HCID 70983218 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | 7-Ethoxy-6-fluoroquinoline-2-carbaldehyde | HCID 86707468 | — |
Reaction Steps
To 7-ethoxy-6-fluoro-2-methylquinoline (180 mg, 0.877 mmol) in dioxane/water (5 mL/0.05 mL) was added selenium dioxide (136 mg, 1.23 mmol) and the reaction was heated to reflux for 2 hours. After cooling, DCM was added followed by MgSO4. After concentration, the residue was used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889704B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-e7587684c5c246f185246021301eaa2d |
| Source note | uspto-grants-2014_11 |