反应详情

To 7-ethoxy-6-fluoro-2-methylquinoline (180 mg, 0.877 mmol) in dioxane/water (5 mL/0.05 mL) was added selenium dioxide (136 mg, 1.23 mmol) and the reaction was heated to reflux for 2 hours. After cooling, DCM was added followed by MgSO4. After concentration, the residue was used in the next step without purification.

1. temperaturethe reaction was heated
2. temperatureto reflux for 2 hours
3. temperatureAfter cooling
4. concentrationAfter concentration
5. customthe residue was used in the next step without purification