反应详情

To a solution of (R)-7-(1-methoxypropan-2-yloxy)-2-methylquinoline (0.22 g, 0.96 mmol) in dioxane (7 mL) and water (0.07 mL) was added selenium dioxide (0.13 g, 1.2 mmol) and the resultant mixture heated at reflux for 2 hours. The cooled reaction mixture was filtered through a plug of Celite® to remove solids, rinsing with dichloromethane. The filtrate was concentrated under reduced pressure and purified by normal phase chromatography on silica gel (10-20% ethyl acetate/hexanes) to afford the title compound (0.11 g, 46%).

1. temperatureat reflux for 2 hours
2. customThe cooled reaction mixture
3. filtrationwas filtered through a plug of Celite®
4. customto remove solids
5. washrinsing with dichloromethane
6. concentrationThe filtrate was concentrated under reduced pressure
7. custompurified by normal phase chromatography on silica gel (10-20% ethyl acetate/hexanes)