Aspirin → HCID 66976703, compound

HRID 339146Notes

Reaction equation

HRID 339146 reaction equation
[OH:1][C@H:2]([CH2:8][C:9](=[O:11])[O-:10])[CH2:3][N+:4]([CH3:7])([CH3:6])[CH3:5].[C:12]([O:15][C:16]1[C:17](=[CH:21][CH:22]=[CH:23][CH:24]=1)[C:18]([OH:20])=[O:19])(=[O:14])[CH3:13]>C(O)C>[C:12]([O:15][C:16]1[C:17](=[CH:21][CH:22]=[CH:23][CH:24]=1)[C:18]([OH:20])=[O:19])(=[O:14])[CH3:13].[OH:1][C@H:2]([CH2:8][C:9](=[O:10])[O-:11])[CH2:3][N+:4]([CH3:7])([CH3:5])[CH3:6]

Participants

4

Reactant 2

HCID 2244AspirinHCID 10917(-)-Carnitine

Product 1

HCID 66976703HCID 66976703, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

L-Carnitine (1.61 g, 10 mmol) and acetylsalicylic acid (1.80 g, 10 mmol) were dissolved in ethanol (20 ml) and the solution concentrated in vacuo at about 40° C. till syrup consistence that on cooling crystallizes. The crystalline mass was triturated with acetone (50 ml), filtered, washed with acetone and dried in vacuo at room temperature. The yield of colorless crystals with m.p. 90-94° C. was 3.17 g (93%). The substance is water soluble, stable at ambient conditions.

Workup

  1. concentrationthe solution concentrated in vacuo at about 40° C. till syrup consistence that
  2. temperatureon cooling
  3. customcrystallizes
  4. customThe crystalline mass was triturated with acetone (50 ml)
  5. filtrationfiltered
  6. washwashed with acetone
  7. customdried in vacuo at room temperature

Sources & evidence

ORD record
ord-94f0c49345d046b6b7eff6d24ae1e96d
Source dataset
uspto-grants-2014_11
Patent number
US08889902B2

Reaction notes

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