Methacryloyl chloride → HCID 58480271, compound

HRID 339426Notes

Reaction equation

[F:1][C:2]([F:39])([C:27]1[CH:32]=[CH:31][C:30]([CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][OH:38])=[CH:29][CH:28]=1)[O:3][C:4]1[CH:25]=[CH:24][C:7]([O:8][C:9]([F:23])([F:22])[C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][OH:21])=[CH:12][CH:11]=2)=[C:6]([CH3:26])[CH:5]=1.[C:40](Cl)(=[O:44])[C:41]([CH3:43])=[CH2:42]>>[C:40]([O:38][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][C:30]1[CH:31]=[CH:32][C:27]([C:2]([O:3][C:4]2[CH:25]=[CH:24][C:7]([O:8][C:9]([C:10]3[CH:11]=[CH:12][C:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:2](=[O:3])[C:27]([CH3:32])=[CH2:28])=[CH:14][CH:15]=3)([F:22])[F:23])=[C:6]([CH3:26])[CH:5]=2)([F:39])[F:1])=[CH:28][CH:29]=1)(=[O:44])[C:41]([CH3:43])=[CH2:42]

Participants

Reactant 2

HCID 13528Methacryloyl chloride

HCID 58480181HCID 58480181, compound

Product 1

HCID 58480271HCID 58480271, compound

Procedure

An analogous synthesis to that described under 1.3. starting from 5-{4-[(4-{difluoro-[4-(5-hydroxypentyl)phenyl]methoxy}-2-methylphenoxy)difluoromethyl]phenyl}pentan-1-ol and methacryloyl chloride gives 5-{4-[(4-{[4-(5-methacryloyloxypentyl)phenyl]difluoromethoxy}-3-methylphenoxy)difluoromethyl]phenyl}pentyl methacrylate as a colourless solid of m.p. 26° C.

Workup

customAn analogous synthesis to that

Sources & evidence

ORD record: ord-bb1f0e407e394515bb7237eb876617e0
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08895117B2

Reaction notes

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