Hydroxyamine hydrochloride → HCID 178454533, compound

HRID 339430Notes

Reaction equation

[C:1]([C:3](=[N:15][O:16][CH2:17][CH:18]([CH3:20])[CH3:19])[C:4]([N:10]1[CH:14]=[N:13][CH:12]=[N:11]1)=[N:5][O:6][CH:7]([CH3:9])[CH3:8])#[N:2].Cl.[NH2:22][OH:23].C([O-])(=O)C.[Na+]>>[OH:23][NH:22][C:1]([C:3](=[N:15][O:16][CH2:17][CH:18]([CH3:20])[CH3:19])[C:4]([N:10]1[CH:14]=[N:13][CH:12]=[N:11]1)=[N:5][O:6][CH:7]([CH3:9])[CH3:8])=[NH:2]

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 517045Sodium Acetate

HCID 86681573HCID 86681573, compound

Product 1

HCID 178454533HCID 178454533, compoundYield 48.4%

Conditions

Temperature: 50 °C

Procedure

(6.04 mmol) of the 1-[2-cyano-2-isobutoxyimino-1-isopropoxyiminoethyl]-1H-1,2,4-triazole produced based on Example 1 were added 0.46 g (6.62 mmol) of hydroxylamine hydrochloride and 0.54 g (6.58 mmol) of sodium acetate, followed by stirring at 50° C. for 3 hours. The solvent in the reaction mixture was distilled off under reduced pressure. The resulting crystal was washed with water and isopropyl ether, to obtain 0.91 g (yield: 48%) of 1-[2-(N-hydroxyamidino)-2-isobutyloxyimino-1-isopropoxyiminoethyl]-1H-1,2,4-triazole.

Workup

distillationThe solvent in the reaction mixture was distilled off under reduced pressure
washThe resulting crystal was washed with water and isopropyl ether

Sources & evidence

ORD record: ord-859b93718cd0410fb8e89d5b21c22877
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08895035B2

Reaction notes

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