Formaldehyde → HCID 67312978, compound

HRID 339516Notes

Reaction equation

HRID 339516 reaction equation
[C:1]([BH3-])#[N:2].[Na+].N[C:6]1[CH:7]=[C:8]([CH:29]=[CH:30][CH:31]=1)[C:9]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[S:19][C:20]3[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[CH:23][C:21]=3[N:22]=2)=[CH:14][CH:13]=1)=[O:10].[CH2:32]=O>CC(O)=O>[CH3:32][N:2]([CH3:1])[C:6]1[CH:7]=[C:8]([CH:29]=[CH:30][CH:31]=1)[C:9]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[S:19][C:20]3[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[CH:23][C:21]=3[N:22]=2)=[CH:14][CH:13]=1)=[O:10]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 5003444Sodium cyanoborohydrideHCID 67312575HCID 67312575, compound

Product 1

HCID 67312978HCID 67312978, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Prepared as described in the Amination section using sodium cyanoborohydride (67 mg, 1.06 mmol), 3-amino-N-[4-(6-methoxybenzothiazol-2-yl)-phenyl]-benzamide (80 mg, 0.213 mmol) and paraformaldehyde (64 mg, 2.13 mmol) in AcOH (2 ml) to give the title compound as colourless plates (53 mg, 62%) after recrystallisation from EtOH.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-2f8ded95431b43c5973d8987be4d46ba
Source dataset
uspto-grants-2014_11
Patent number
US08895313B2

Reaction notes

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