Stannous chloride dihydrate → HCID 11359587, compound

HRID 339557Notes

Reaction equation

HRID 339557 reaction equation
[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1.O.O.[Sn](Cl)Cl>CCO>[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 11210748HCID 11210748, compound

Product 1

HCID 11359587HCID 11359587, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared as described in the Nitro Reduction section using 6-iodo-2-(4-nitrophenyl)imidazo[1,2-a]pyridine (0.45 g, 1.23 mmol) and tin (II) dichloride dihydrate (1.39 g, 6.16 mmol) in EtOH (25 ml) to give the title compound (0.301 g, 73%) as a yellow solid, after work-up and flash chromatography (4:1 EtOAc/DCM).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-9bb4d97a2c95472ab5dd4142176bd8f0
Source dataset
uspto-grants-2014_11
Patent number
US08895313B2

Reaction notes

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