反应详情

To a stirred solution of 3,5-difluoro-4-methoxybenzoic acid (0.25 g, 1.34 mmol) in thionyl chloride (4 ml) was added a drop of DMF and the reaction mixture was then heated under reflux for 5 h. On cooling to room temperature the excess reagent was removed under reduced pressure to give a crude residue. The amide was prepared as described in the Amide Coupling section using the crude residue and 4-(6-methylimidazo[1,2-a]pyridin-2-yl)aniline (0.30 g, 1.34 mmol) in dry pyridine (14 ml) to give the title compound (0.33 g, 62%) as a pale yellow solid after work-up and flash chromatography (DCM/MeOH 20:1).

1. temperaturethe reaction mixture was then heated
2. temperatureunder reflux for 5 h
3. customwas removed under reduced pressure
4. customto give a crude residue
5. customThe amide was prepared