Stannous chloride dihydrate → 3-(2-fluoroethoxy)-4-{(E)-2-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]ethenyl}aniline

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Reaction Steps

Prepared as described in the Nitro Reduction section using 2-(4-{(E)-2-[4-nitro-2-(2-fluoroethoxy)phenyl]ethenyl}phenyl)-6-methylimidazo[1,2-a]pyridine (81 mg, 0.194 mmol) and tin (II) dichloride dihydrate (219 mg, 0.970 mmol) in EtOH (12 ml) to give the title compound (36 mg, 48%) as an orange solid after work-up and flash chromatography (2:1 EtOAc/DCM).

Provenance & Evidence