2-Hydrazinopyridine → HCID 67233679, compound

HRID 339697Notes

Reaction equation

HRID 339697 reaction equation
[Br:1][C:2]1[C:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:20]=O)=[N:9]2)=[CH:4][CH:3]=1.[NH:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1)[NH2:23]>CCO>[Br:1][C:2]1[C:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:20]=[N:23][NH:22][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=3)=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 786452-HydrazinopyridineHCID 86654355HCID 86654355, compound

Product 1

HCID 67233679HCID 67233679, compoundYield 80.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To the product from Step C (2.95 g, 8.05 mmol) was added EtOH (30 mL, anhydrous). To this solution was added 2-hydrazinylpyridine (0.967 g, 8.86 mmol). The mixture was stirred at ambient temperature for 24 hours. The resulting precipitate was isolated by vacuum filtration and washed with cold EtOH and then dried in vacuo to afford 2.98 g (73%) of the desired product.

Workup

  1. customThe resulting precipitate was isolated by vacuum filtration
  2. washwashed with cold EtOH
  3. customdried in vacuo

Sources & evidence

ORD record
ord-02e6e734ea0440f2845aa63c37550da8
Source dataset
uspto-grants-2014_11
Patent number
US08895550B2

Reaction notes

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