反应详情

温度

0 °C

To a solution of ethyl 2-cyano-4-oxo-4-phenylbutanoate (8 g, 34.6 mmol) in Et2O (100 ml) was bubbled HCl gas at 0° C. for 30 min. After reaction mixture was stirred for 1 day at 0° C., the resulting solution was evaporated under reduced pressure. The residue was purified with silica gel column (EtOAc:Hx=1:3) to produce title compound (7.3 g, 84.5%) as light yellow solid.

1. customAfter reaction mixture
2. customthe resulting solution was evaporated under reduced pressure
3. customThe residue was purified with silica gel column (EtOAc:Hx=1:3)