反应详情

Benzyl 3-hydroxypropylcarbamate (15 g, 72 mmol) was treated with imidazole (10 g, 146.9 mmol) and TBSCl (12 g, 79.6 mmol) in DMF (10 ml) at 0° C. After warming up the reaction mixture to room temperature, it was stirred for 30 minutes. The resulting solution was quenched with water (50 ml), and then extracted with diethyl ether (50 ml×2) twice. After evaporation of volatile material under reduced pressure, the residue was purified with silica gel column chromatography (EtOAc:Hx=1:10) to afford title compound (23 g, 98%) as colorless oil.

1. customThe resulting solution was quenched with water (50 ml)
2. extractionextracted with diethyl ether (50 ml×2) twice
3. customAfter evaporation of volatile material under reduced pressure
4. customthe residue was purified with silica gel column chromatography (EtOAc:Hx=1:10)