(-)-Glycidol → (S)-glycidyl methanesulfonate

HRID 339767Notes

Reaction equation

HRID 339767 reaction equation
[CH3:1][S:2]([O:5][CH2:6][C@@H:7]1[O:9][CH2:8]1)(=[O:4])=[O:3].C1O[C@H]1CO>>[CH3:1][S:2]([O:5][CH2:6][C@H:7]1[O:9][CH2:8]1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 6973630(-)-GlycidolHCID 12461091HCID 12461091, compound

Product 1

HCID 12461090(S)-glycidyl methanesulfonate

Procedure

(S)-Glycidyl Methanesulfonate was synthesized in an analogous manner to Intermediate F, Step 1, substituting (R)-(+)-glycidol for (S)-(−)-glycidol. This was used in further transformations as a solution of (S)-glycidyl methanesulfonate in DMF, without further purification.

Workup

  1. customThis was used in further transformations as a solution of (S)-glycidyl methanesulfonate in DMF, without further purification

Sources & evidence

ORD record
ord-6e7750a4e56947da837f0576cfca4275
Source dataset
uspto-grants-2014_11
Patent number
US08895549B2

Reaction notes

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