(2-Amino-4,5-dimethoxy-phenyl)-[2-(acetoxymethyl)-pyrrolidin-1-yl]-methanone → (2-Hydroxymethyl-pyrrolidin-1-yl)-(2-isocyanato-4,5-dimethoxy-phenyl)-methanone

HRID 33984Notes

Reaction equation

HRID 33984 reaction equation
NC1C=C(OC)C(OC)=CC=1C(N1CCCC1COC(=O)C)=O.C([SiH2][O:29][C:30](C)(C)[CH:31]1[CH2:35][CH2:34][CH2:33][N:32]1[C:36]([C:38]1[CH:43]=[C:42]([O:44][CH3:45])[C:41]([O:46][CH3:47])=[CH:40][C:39]=1[N:48]=[C:49]=[O:50])=[O:37])(C)(C)C>>[OH:29][CH2:30][CH:31]1[CH2:35][CH2:34][CH2:33][N:32]1[C:36]([C:38]1[CH:43]=[C:42]([O:44][CH3:45])[C:41]([O:46][CH3:47])=[CH:40][C:39]=1[N:48]=[C:49]=[O:50])=[O:37]

Participants

3

Reactant 2

HCID 69032329(2-Amino-4,5-dimethoxy-phenyl)-[2-(acetoxymethyl)-pyrrolidin-1-yl]-methanoneHCID 131727078[2-(tert-Butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-(2-isocyanato-4,5-dimethoxy-phenyl)-methanone

Product 1

HCID 86609298(2-Hydroxymethyl-pyrrolidin-1-yl)-(2-isocyanato-4,5-dimethoxy-phenyl)-methanone

Procedure

This was prepared from (6) in the same manner as above for (7).

Sources & evidence

ORD record
ord-2283df3c1040444e9223aa500008ea35
Source dataset
uspto-grants-2008_09
Patent number
US07429658B2

Reaction notes

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