Tetramethyl orthocarbonate → HCID 68359324, compound

HRID 339914Notes

Reaction equation

HRID 339914 reaction equation
[OH:1][C:2]([CH3:23])([CH3:22])[CH:3]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[CH:10][CH:9]=1)[S:4]([NH2:7])(=[O:6])=[O:5].[C:24](OC)(OC)(OC)[O:25][CH3:26]>C(O)(=O)C>[CH3:24][O:25][C:26]1[O:1][C:2]([CH3:23])([CH3:22])[CH:3]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)=[CH:10][CH:9]=2)[S:4](=[O:5])(=[O:6])[N:7]=1

Participants

4

Reactant 2

HCID 74613Tetramethyl orthocarbonateHCID 68291820HCID 68291820, compound

Product 1

HCID 68359324HCID 68359324, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2-Hydroxy-2-methyl-1-[4-(2-morpholin-4-ylethyl)phenyl]propane-1-sulfonamide (44 mg) was stirred with tetramethyl orthocarbonate (1 ml) and glacial acetic acid (0.2 ml) at 80° C. for 17 hours. The solvents were removed under reduced pressure. This gave the crude product with a molecular weight of 382.5 g/mol (C18H26N2O5S), which was used without further purification.

Workup

  1. customThe solvents were removed under reduced pressure

Sources & evidence

ORD record
ord-d6d98ce2195941a988d9f0a1fb4715f8
Source dataset
uspto-grants-2014_11
Patent number
US08895547B2

Reaction notes

Loading…