Hydrochloric Acid → HCID 86681452, compound

HRID 339958Notes

Reaction equation

HRID 339958 reaction equation
[OH:1][CH2:2][C@@H:3]([NH:17]C(=O)OC(C)(C)C)[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=2)[CH:6]=1.CO.Cl.O1CCOCC1>>[NH2:17][C@@H:3]([CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=2)[CH:6]=1)[CH2:2][OH:1]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 312751,4-DioxaneHCID 86681453HCID 86681453, compound

Product 1

HCID 86681452HCID 86681452, compound

Procedure

The product of Step A (0.45 g, 1.4 mmol) was combined with methanol (2.0 mL, 49 mmol) and 4.0 M HCl in dioxane (6.0 mL, 24 mmol). The reaction mixture was stirred at rt for 30 min yielding the titled compound. LC-MS found: 232.2 (m+1).

Sources & evidence

ORD record
ord-5b8829bd22db451b9f04bc6d93021b71
Source dataset
uspto-grants-2014_11
Patent number
US08895571B2

Reaction notes

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