Hydrochloric Acid → HCID 178436891, compound

HRID 340074Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][C:11]2[N:14](COCC[Si](C)(C)C)[C:15]([C:17]3[C:25]4[C:20](=[CH:21][C:22]([C:26]5[CH:31]=[C:30]([F:32])[C:29]([O:33][CH3:34])=[CH:28][C:27]=5[CH2:35][CH3:36])=[CH:23][CH:24]=4)[N:19](C4CCCCO4)[N:18]=3)=[N:16][C:10]=2[CH2:9]1)=O)(C)(C)C.[ClH:51]>CO>[ClH:51].[ClH:51].[ClH:51].[CH2:35]([C:27]1[CH:28]=[C:29]([O:33][CH3:34])[C:30]([F:32])=[CH:31][C:26]=1[C:22]1[CH:21]=[C:20]2[C:25]([C:17]([C:15]3[NH:14][C:11]4[CH2:12][CH2:13][NH:8][CH2:9][C:10]=4[N:16]=3)=[N:18][NH:19]2)=[CH:24][CH:23]=1)[CH3:36]

Participants

Conditions

Temperature: 60 °C

Procedure

To a solution of 2-[6-(2-ethyl-5-fluoro-4-methoxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-indazol-3-yl]-1-(2-trimethylsilanyl-ethoxymethyl)-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester (Preparation 23, 801 mg, 1.13 mmol) in methanol (20 mL) was added concentrated hydrochloric acid (12M, 8 mL) and the resulting solution was heated at 60° C. for 18 hours. The reaction mixture was cooled to room temperature and concentrated in vacuo to furnish the title compound (739 mg).

Workup

temperatureThe reaction mixture was cooled to room temperature
concentrationconcentrated in vacuo

Sources & evidence

ORD record: ord-93e61e84487d4a91aeac792d1b7fef3a
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08895544B2

Reaction notes

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