Phosphorus oxychloride → 3-(3-fluorophenyl)-5-chloro-1H-pyrazolo[4,3-b]pyridine

HRID 34008Notes

Reaction equation

HRID 34008 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:12]3=[N+:13]([O-])[CH:14]=[CH:15][CH:16]=[C:11]3[N:10](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1.P(Cl)(Cl)([Cl:39])=O>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:12]3=[N:13][C:14]([Cl:39])=[CH:15][CH:16]=[C:11]3[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 23070186HCID 23070186, compound

Product 1

HCID 230701163-(3-fluorophenyl)-5-chloro-1H-pyrazolo[4,3-b]pyridine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

To 100 mg of 3-(3-fluorophenyl)-1-trityl-1H-pyrazolo[4,3-b]pyridine-4-oxide in toluene was acted phosphorus oxychloride in toluene in the same manner as described in Production example 28, to afford 30 mg of 3-(3-fluorophenyl)-5-chloro-1H-pyrazolo[4,3-b]pyridine described in Example 38 described below as a colorless powder, as well as 60 mg of a crude product of the title compound as a colorless powder.

Sources & evidence

ORD record
ord-bc7a8d2a242f418e98070a183a01b284
Source dataset
uspto-grants-2008_09
Patent number
US07429609B2

Reaction notes

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