反应详情

The imidazo[4,5-c]quinoline system is synthesised starting from 4-chloro-3-nitroquinolines D which are activated in the 6-position by a leaving group EWG, for example halogen, triflate or mesylate. Preferably 4-chloro-6-iodo-3-nitro-quinoline (D.1) or 6-bromo-4-chloro-3-nitro-quinoline (D.2) is used.