反应详情

A 0.6 g quantity of 10% palladium carbon was added to 100 ml of a DMF solution containing 5.7 g of trans-1,4-bis[[1-cyclohexyl-3-(4-nitrophenyl)ureido]-metyl]cyclohexane synthesized in accordance with Example 2. Hydrogen was added at ordinal pressure and normal temperature for 15 hours. After completion of the reaction, palladium was separated by filtration and the reaction mixture was concentrated under reduced pressure. The reaction mixture was dissolved in chloroform and a 4N hydrochloric acid-dioxyane solution was added to provide 5.5 g (95%) of white crystals precipitated.

1. customsynthesized in accordance with Example 2
2. customwas separated by filtration
3. concentrationthe reaction mixture was concentrated under reduced pressure
4. dissolutionThe reaction mixture was dissolved in chloroform
5. additiona 4N hydrochloric acid-dioxyane solution was added