反应详情

温度

50 °C

To a solution of 1.18 g of (2-chlorothiophen-3-yl)-(naphthalen-2-yl)-methanol in 12 mL of toluene was added 1.12 g of activated manganese dioxide at room temperature, and after stirring at 50° C. for a day, manganese dioxide was filtered off through Celite. The solvent was distilled off, and the resultant crude product was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=1:50), to afford 0.61 g of the title compound as a colorless oil.

1. filtrationmanganese dioxide was filtered off through Celite
2. distillationThe solvent was distilled off
3. customthe resultant crude product was purified
4. customseparated by silica gel column chromatography (ethyl acetate:n-hexane=1:50)