(2-Chlorothiophen-3-yl)naphthalen-2-yl Methanol → (2-Chlorothiophen-3-yl)-(naphthalen-2-yl)-methanone

Participants

Reaction Conditions

Reaction Steps

To a solution of 1.18 g of (2-chlorothiophen-3-yl)-(naphthalen-2-yl)-methanol in 12 mL of toluene was added 1.12 g of activated manganese dioxide at room temperature, and after stirring at 50° C. for a day, manganese dioxide was filtered off through Celite. The solvent was distilled off, and the resultant crude product was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=1:50), to afford 0.61 g of the title compound as a colorless oil.

Provenance & Evidence