2-Furancarboxylic acid → Furan-2-carboxylic acid {7-fluoro-1-(furan-2-carbonyl)-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazole-5-yl}-amide

Participants

Role	Name	HCID	Charge
Reactant	2-Furancarboxylic acid	HCID 6919	—
Reactant	7-fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazol-5-ylamine	HCID 178507809	—
Product	Furan-2-carboxylic acid {7-fluoro-1-(furan-2-carbonyl)-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazole-5-yl}-amide	HCID 59797182	37.9%

Reaction Steps

Following amidation using 217 mg of 7-fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazol-5-ylamine and 286 mg of 2-furancarboxylic acid in accordance with the method of Example 127, purification by LC-MS was carried out, to afford 143 mg of the title compound as yellow crystals.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07429609B2
Source dataset	uspto-grants-2008_09
ORD ID	ord-01a90d08fb0a473ea7da21d086405516
Source note	uspto-grants-2008_09